Helicobacter pylori is a common and important human pathogen and the primary cause of peptic ulcer disease and gastric cancer. H. pylori is transmitted between humans and is facilitated by poor household hygiene and sanitary conditions. The pathogen causes progressive gastric mucosal inflammation that might eventuate in atrophic gastritis and gastric atrophy. For a population, elimination of H. pylori will essentially eliminate gastric cancer risk. For the individual, H. pylori eradication will reduce gastric cancer risk depending on the extent of damage (that is, level of risk) when eradication is accomplished. Where gastric cancer is common, H. pylori eradication should be coupled with assessment of cancer risk to identify whether surveillance for gastric cancer is indicated. This poster helps to understand various aspects of H. pylori infection.
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(Source of poster: Nature Reviews Gastroenterology & Hepatology)