MDR-GN

  • Target indication: Infections caused by multidrug resistant Gram-negative bacteria in the hospital setting

    The management of infections caused by multidrug resistant gram-negative bacteria (MDR-GN) represents one of the major unmet medical needs in infectious diseases. Antibiotic resistance caused about 23,000 deaths in 2013 in the United States and this number is expected to reach 1 million globally by 2050. Among the MDR-GNs, extended-spectrum β-lactamases (ESBL) producing Enterobacter, carbapenemase-producing Enterobacteriaceae, multidrug resistant Pseudomonas aeruginosa and multidrug resistant Acinetobacter Baumanii represent the biggest threats to human health.

    By utilizing our unique multi-targeting drug discovery platform and expertise in infectious disease R&D area, TenNor is working on several promising lead series with potential to address the major unmet medical needs in this area.